Article
Structures of Merkel cell polyomavirus VP1 complexes define a sialic acid binding site required for infection.
PLoS pathogens - 1 Jan 2012
Neu Ursula, Hengel Holger, Blaum Bärbel S, Schowalter Rachel M, Macejak Dennis, Gilbert Michel, Wakarchuk Warren W, Imamura Akihiro, Ando Hiromune, Kiso Makoto, Arnberg Niklas, Garcea Robert L, Peters Thomas, Buck Christopher B, Stehle Thilo
Abstract excerpt
The recently discovered human Merkel cell polyomavirus (MCPyV or MCV) causes the aggressive Merkel cell carcinoma (MCC) in the skin of immunocompromised individuals. Conflicting reports suggest that cellular glycans containing sialic acid (Neu5Ac) may play a role in MCPyV infectious entry. To address this question, we solved X-ray structures of the MCPyV major capsid protein VP1 both alone and in complex with...
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