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Structural and functional analysis of natural capsid variants suggests sialic acid-independent entry of BK polyomavirus

1 Feb 2023

Abstract excerpt

BK polyomavirus (BKPyV) is an opportunistic pathogen that uses the b-series gangliosides GD1b and GT1b as entry receptors. Here, we characterize the impact of naturally occurring VP1 mutations on ganglioside binding, VP1 protein structure, and virus tropism. Infectious entry of single mutants E73Q and E73A and the triple mutant A72V-E73Q-E82Q (VQQ) remains sialic acid dependent, and all three variants acquire...

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Antenna Design and Analysis
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Polyomavirus and related diseases

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 36790933
DOI: 10.1016/j.celrep.2023.112114

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