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Article

Functional profiling of receptor tyrosine kinases and downstream signaling in human chondrosarcomas identifies pathways for rational targeted therapy.

Clinical cancer research : an official journal of the American Association for Cancer Research - 15 Jul 2013

Zhang Yi-Xiang, van Oosterwijk Jolieke G, Sicinska Ewa, Moss Samuel, Remillard Stephen P, van Wezel Tom, Bühnemann Claudia, Hassan Andrew B, Demetri George D, Bovée Judith V M G, Wagner Andrew J

Abstract excerpt

PURPOSE: Chondrosarcomas are notoriously resistant to cytotoxic chemotherapeutic agents. We sought to identify critical signaling pathways that contribute to their survival and proliferation, and which may provide potential targets for rational therapeutic interventions. EXPERIMENTAL DESIGN: Acti...

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Identifiers

PMID: 23714727
DOI: 10.1158/1078-0432.CCR-12-3647

Genes

NRAS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-23714727-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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