Article
Aberrant methylation of breast and ovarian cancer susceptibility gene 1 in chemosensitive human ovarian cancer cells does not involve the phosphatidylinositol 3'-kinase-Akt pathway.
Cancer science - 1 Jul 2010
Wang Yan-Qiu, Zhang Jia-Rong, Li Shuang-Di, He Yin-Yan, Yang Yi-Xia, Liu Xue-Lian, Wan Xiao-Ping
Abstract excerpt
Methylation is an important silencing mechanism of breast and ovarian cancer susceptibility gene 1 (BRCA1) expression in sporadic ovarian cancer. However, the role of BRCA1 methylation in chemotherapy in sporadic ovarian cancer and the related pathways have not been understood completely. This study has determined the roles of BRCA1 hypermethylation in chemotherapy of sporadic ovarian cancer and its related...
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