Article
Cardiac phenotyping in ex vivo murine embryos using microMRI.
NMR in biomedicine - 1 Oct 2009
Cleary Jon O, Price Anthony N, Thomas David L, Scambler Peter J, Kyriakopoulou Vanessa, McCue Karen, Schneider Jürgen E, Ordidge Roger J, Lythgoe Mark F
Abstract excerpt
Microscopic MRI (microMRI) is an emerging technique for high-throughput phenotyping of transgenic mouse embryos, and is capable of visualising abnormalities in cardiac development. To identify cardiac defects in embryos, we have optimised embryo preparation and MR acquisition parameters to maximise image quality and assess the phenotypic changes in chromodomain helicase DNA-binding protein 7 (Chd7) transgenic...
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