Article
Microcomputed tomography provides high accuracy congenital heart disease diagnosis in neonatal and fetal mice.
Circulation. Cardiovascular imaging - 1 Jul 2013
Kim Andrew J, Francis Richard, Liu Xiaoqin, Devine William A, Ramirez Ricardo, Anderton Shane J, Wong Li Yin, Faruque Fahim, Gabriel George C, Chung Wendy, Leatherbury Linda, Tobita Kimimasa, Lo Cecilia W
Abstract excerpt
BACKGROUND: Mice are well suited for modeling human congenital heart disease (CHD), given their 4-chamber cardiac anatomy. However, mice with CHD invariably die prenatally/neonatally, causing CHD phenotypes to be missed. Therefore, we investigated the efficacy of noninvasive microcomputed tomography (micro-CT) to screen for CHD in stillborn/fetal mice. These studies were performed using chemically mutagenized...
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