Article
Magnetic resonance virtual histology for embryos: 3D atlases for automated high-throughput phenotyping.
NeuroImage - 15 Jan 2011
Cleary Jon O, Modat Marc, Norris Francesca C, Price Anthony N, Jayakody Sujatha A, Martinez-Barbera Juan Pedro, Greene Nicholas D E, Hawkes David J, Ordidge Roger J, Scambler Peter J, Ourselin Sebastien, Lythgoe Mark F
Abstract excerpt
Ambitious international efforts are underway to produce gene-knockout mice for each of the 25,000 mouse genes, providing a new platform to study mammalian development and disease. Robust, large-scale methods for morphological assessment of prenatal mice will be essential to this work. Embryo phenotyping currently relies on histological techniques but these are not well suited to large volume screening. The...
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