Article

Efficient murine cardiac phenotyping by combining synchrotron-based phase-contrast micro-CT, histology, immunofluorescence and spatial transcriptomics

2026-04-28

Abstract excerpt

1. Congenital heart disease is commonly studied using genetically modified mouse models, but characterization of complex three-dimensional (3D) cardiac anomalies remains technically challenging. Histology of fixed paraffin-embedded samples, typically used for structural and molecular analysis, is limited to two dimensions (2D). Synchrotron radiation-based phase-contrast micro-computed tomography (SRPC-µCT) enables...

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Literature Corpus work: 1b06202c-a6f0-5158-8b2f-ca7fc96a87e0
DOI: 10.64898/2026.04.24.720617

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