Article
Introducing a single‐cell‐derived human mesenchymal stem cell line expressing hTERT after lentiviral gene transfer
4 Mar 2008
Abstract excerpt
Human mesenchymal stem cells (hMSCs) can be readily isolated from bone marrow and differentiate into multiple tissues, making them a promising target for future cell and gene therapy applications. The low frequency of hMSCs in bone marrow necessitates their isolation and expansion in vitro prior to clinical use, but due to senescence-associated growth arrest during culture, limited cell numbers can be generated....
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