Article
Genetic polymorphisms of low density lipoprotein receptor can modify stroke presentation.
Neurological research - 1 Jun 2010
Lee Jiann-Der, Lin Ya-Hui, Hsu Huan-Lin, Huang Yen-Chu, Wu Chih-Ying, Ryu Shan-Jin, Lee Meng, Huang Ying-Chih, Hsiao Ming-Chang, Chang Yeu-Jhy, Chang Chien-Hung, Lee Tsong-Hai
Abstract excerpt
Low density lipoprotein is transcytosed across the blood-brain barrier mediated by low density lipoprotein receptor (LDLR). LDLR in the brain is mainly expressed on capillary endothelial cells and is therefore considered to be an important susceptibility gene in modifying the stroke presentation. A HapMap-based haplotype-tagging single nucleotide polymorphism association study was conducted in an isolated...
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