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Article

Overexpression of Sp1 leads to p53‐dependent apoptosis in cancer cells

11 May 2009

Abstract excerpt

Numerous studies have documented that Sp1 expression level were elevated in various human cancers. However, the promoters of many pro-apoptotic genes have been found to contain the Sp1 binding elements and are activated by Sp1 overexpression. To better understand the role and the mechanism of increased Sp1 levels on apoptosis, we used adenovirus to ectopically express GFP-Sp1 protein in various cancer cell lines....

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PMID: 19588484
DOI: 10.1002/ijc.24563

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