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Article

Caspase cleavage of transcription factor Sp1 enhances apoptosis.

Apoptosis : an international journal on programmed cell death - 1 Jan 2018

Torabi Behzad, Flashner Samuel, Beishline Kate, Sowash Aislinn, Donovan Kelly, Bassett Garrett, Azizkhan-Clifford Jane

Abstract excerpt

Sp1 is a ubiquitous transcription factor that regulates many genes involved in apoptosis and senescence. Sp1 also has a role in the DNA damage response; at low levels of DNA damage, Sp1 is phosphorylated by ATM and localizes to double-strand break sites where it facilitates DNA double-strand-break repair. Depletion of Sp1 increases the sensitivity of cells to DNA damage, whereas overexpression of Sp1 can drive...

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PMID: 29236199
DOI: 10.1007/s10495-017-1437-4

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ATM

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