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Article

BAP1 induces cell death via interaction with 14-3-3 in neuroblastoma

19 Apr 2018

Abstract excerpt

BRCA1-associated protein 1 (BAP1) is a nuclear deubiquitinating enzyme that is associated with multiprotein complexes that regulate key cellular pathways, including cell cycle, cellular differentiation, cell death, and the DNA damage response. In this study, we found that the reduced expression of BAP1 pro6motes the survival of neuroblastoma cells, and restoring the levels of BAP1 in these cells facilitated a...

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PMID: 29686263
DOI: 10.1038/s41419-018-0500-6

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