Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

MiR-539 inhibits the malignant behavior of breast cancer cells by targeting SP1.

Biochemistry and cell biology = Biochimie et biologie cellulaire - 1 Jun 2020

Cai Fenglin, Chen Luhong, Sun Yuting, He Chunlan, Fu Deyuan, Tang Jinhai

Abstract excerpt

The aberrant expression of microRNAs (miRNAs) is involved in the initiation and progression of human cancers. In our study, we found that miR-539 was down-regulated in breast cancer tissues and cell lines. Decreased expression of miR-539 was significantly associated with lymph node metastasis in patients with breast cancer. Overexpression of miR-539 inhibited the proliferation and promoted apoptosis of breast...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Movement
Share to Cisplatin
Share to Epithelial-Mesenchymal Transition

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Lymphatic Metastasis

Share to MCF-7 Cells

Share to Neoplasm Invasiveness

Share to Neoplasm Metastasis

Share to Sp1 Transcription Factor

Source

Identifiers

PMID: 31742423
DOI: 10.1139/bcb-2019-0111

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

MiR-539 inhibits the malignant behavior of breast cancer cells by targeting SP1.PMID 31742423Read ↗

The oncogenic microRNA-27a targets genes that regulate specificity protein transcription factors and the G2-M checkpoint in MDA-MB-231 breast cancer cells.Semantic proximity Read ↗

Integrated high-throughput analysis identifies Sp1 as a crucial determinant of p53-mediated apoptosisSemantic proximity Read ↗

Reactivating p53 functions by suppressing its novel inhibitor iASPP: a potential therapeutic opportunity in p53 wild-type tumorsSemantic proximity Read ↗

Down-regulated lncRNA SBF2-AS1 inhibits tumorigenesis and progression of breast cancer by sponging microRNA-143 and repressing RRS1Semantic proximity Read ↗

LRP11-AS1 Promotes the Malignant Behavior of Triple Negative Breast Cancer Cells via the MiR-149-3p/NRP2 AxisSemantic proximity Read ↗

lncRNA HCG11 regulates the expression level of SP1 as a potential prognostic biomarker of BC during the polymerase II transcription process in an HCG11/miR-106a-3p/SP1 axis: integrated bioinformatics and experimental investigationSemantic proximity Read ↗

MiR-142-5p Acts as a Significant Regulator Through Promoting Proliferation, Invasion, and Migration in Breast Cancer Modulated by Targeting SORBS1Semantic proximity Read ↗

New insight into the role of substance P/neurokinin‐1 receptor system in breast cancer progression and its crosstalk with microRNAsSemantic proximity Read ↗

MiR-93-5p inhibits the EMT of breast cancer cells via targeting MKL-1 and STAT3Semantic proximity Read ↗

MiR-519e-5p regulates malignant phenotype of breast cancer cells through binding to CTPS1.Semantic proximity Read ↗

MiR-519d impedes cisplatin-resistance in breast cancer stem cells by down-regulating the expression of MCL-1Semantic proximity Read ↗

SGCE promotes breast cancer stemness by promoting the transcription of FGF-BP1 by Sp1Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.