Article
Influence of mutations in the hepatitis B virus genome on virus replication and drug resistance--implications for novel antiviral strategies.
Current medicinal chemistry - 1 Oct 2004
Tacke Frank, Manns Michael P, Trautwein Christian
Abstract excerpt
Persistent infection with the hepatitis B virus (HBV) represents a major health problem worldwide with over 350 million patients at risk of developing liver cirrhosis or hepatocellular carcinoma. HBV is a small, partially double-stranded DNA virus with four overlapping genes and a unique life cycle, creating an intracellular pool of covalently closed circular DNA molecules for persistence and an RNA template for...
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