Article
Role of CXCR4/SDF-1 alpha in the migratory phenotype of hepatoma cells that have undergone epithelial-mesenchymal transition in response to the transforming growth factor-beta.
Cellular signalling - 1 Nov 2009
Bertran Esther, Caja Laia, Navarro Estanis, Sancho Patricia, Mainez Jèssica, Murillo Miguel M, Vinyals Antonia, Fabra Angels, Fabregat Isabel
Abstract excerpt
Treatment of FaO rat hepatoma cells with TGF-beta selects cells that survive to its apoptotic effect and undergo epithelial-mesenchymal transitions (EMT). We have established a cell line (T beta T-FaO, from TGF-beta-treated FaO) that shows a mesenchymal, de-differentiated, phenotype in the presence of TGF-beta and is refractory to its suppressor effects. In the absence of this cytokine, cells revert to an...
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