Article

Excess Serum Interleukin-18 Distinguishes Patients with Pathogenic Mutations in <i>PSTPIP1</i>

2021-02-23

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Objective</h4> Dominantly-inherited mutations in PSTPIP1 cause a family of monogenic autoinflammatory diseases epitomized by Pyogenic Arthritis, Pyoderma gangrenosum, and Acne (PAPA) syndrome. The connections between PSTPIP1 and PAPA are poorly understood, although in vitro evidence suggests increased activation of the pyrin-inflammasome. We sought to identify biomarkers of potential mechanis...

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Literature Corpus work: 1c1367a2-b5ba-509e-8514-83540971e567
DOI: 10.1101/2021.02.22.21251857

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