Article
Tissue factor gene polymorphisms and haplotypes and the risk of ischemic vascular events: four studies and a meta-analysis.
Journal of thrombosis and haemostasis : JTH - 1 Sept 2009
DE Gaetano M, Quacquaruccio G, Pezzini A, Latella M C, DI Castelnuovo A, Del Zotto E, Padovani A, Lichy C, Grond-Ginsbach C, Gattone M, Giannuzzi P, Nowak M, Novak N, Dorn J, Trevisan M, Donati M B, Iacoviello L
Abstract excerpt
OBJECTIVE: The exposure of tissue factor (TF) to blood flow is the initial step in the coagulation process and plays an important role in thrombogenesis. We investigated the role of genetic polymorphisms and haplotypes of the TF gene in the risk of ischemic vascular disease. METHODS: Four hundred and twenty-two Italian patients with juvenile myocardial infarction (MI) and 434 controls, 808 US cases with MI and...
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