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Article

Biosynthesis of riboflavin. Screening for an improved GTP cyclohydrolase II mutant.

The FEBS journal - 1 Aug 2009

Lehmann Martin, Degen Simone, Hohmann Hans-Peter, Wyss Markus, Bacher Adelbert, Schramek Nicholas

Abstract excerpt

GTP cyclohydrolase II catalyzes the first dedicated step in the biosynthesis of riboflavin and appears to be a limiting factor for the production of the vitamin by recombinant Bacillus subtilis overproducer strains. Using error-prone PCR amplification, we generated a library of the B. subtilis ribA gene selectively mutated in the GTP cyclohydrolase II domain. The ratio of the GTP cyclohydrolase II to...

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PMID: 19583770
DOI: 10.1111/j.1742-4658.2009.07118.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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