Article
Polymorphisms in the neurokinin-2 receptor gene are associated with angiotensin-converting enzyme inhibitor-induced cough.
Journal of clinical pharmacy and therapeutics - 1 Aug 2009
Kim T-B, Oh S-Y, Park H-K, Jeon S-G, Chang Y-S, Lee K-Y, Cho Y S, Chae I-H, Kim Y-K, Cho S-H, Moon H-B, Min K-U, Kim Y-Y
Abstract excerpt
BACKGROUND AND OBJECTIVE: Treatment with angiotensin-converting enzyme (ACE) inhibitors can induce chronic cough in many patients. Genetic variations in the neurokinin 2 receptor gene (NK2R) are significantly associated with cough sensitivity to capsaicin. METHODS: This study assessed the relationship between genetic polymorphisms in the NK2R gene and chronic cough in 91 patients taking ACE inhibitors. Patients...
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