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Article

Inter-individual variability of plasma PAF-acetylhydrolase activity in ARDS patients and PAFAH genotype.

Journal of clinical pharmacy and therapeutics - 1 Aug 2009

Li S, Stuart L, Zhang Y, Meduri G U, Umberger R, Yates C R

Abstract excerpt

BACKGROUND: Platelet activating factor (PAF), a pro-inflammatory phospholipid, stimulates cytokine secretion from polymorphonuclear leukocytes expressing the transmembrane G-protein coupled PAF receptor. Elevated PAF levels are associated with acute respiratory distress syndrome (ARDS) and sepsis severity. The pro-inflammatory effects of PAF are terminated by PAF acetylhydrolase (PAF-AH). OBJECTIVE: We sought to...

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Identifiers

PMID: 19583678
DOI: 10.1111/j.1365-2710.2008.01014.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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