Article
Maternal overnutrition programs changes in the expression of skeletal muscle genes that are associated with insulin resistance and defects of oxidative phosphorylation in adult male rat offspring.
The Journal of nutrition - 1 Mar 2014
Latouche Celine, Heywood Sarah E, Henry Sarah L, Ziemann Mark, Lazarus Ross, El-Osta Assam, Armitage James A, Kingwell Bronwyn A
Abstract excerpt
Children of obese mothers have increased risk of metabolic syndrome as adults. Here we report the effects of a high-fat diet in the absence of maternal obesity at conception on skeletal muscle metabolic and transcriptional profiles of adult male offspring. Female Sprague Dawley rats were fed a diet rich in saturated fat and sucrose [high-fat diet (HFD): 23.5% total fat, 9.83% saturated fat, 20% sucrose wt:wt] or...
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