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Article

Dynamics of locking of peptides onto growing amyloid fibrils.

Proceedings of the National Academy of Sciences of the United States of America - 21 Jul 2009

Reddy Govardhan, Straub John E, Thirumalai D

Abstract excerpt

Sequence-dependent variations in the growth mechanism and stability of amyloid fibrils, which are implicated in a number of neurodegenerative diseases, are poorly understood. We have carried out extensive all-atom molecular dynamics simulations to monitor the structural changes that occur upon addition of random coil (RC) monomer fragments from the yeast prion Sup35 and Abeta-peptide onto a preformed fibril....

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Identifiers

PMID: 19581575
DOI: 10.1073/pnas.0902473106
PMCID: PMC2715474

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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