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Article

Helix H1 of the prion protein is rather stable against environmental perturbations: molecular dynamics of mutation and deletion variants of PrP(90-231).

Cellular and molecular life sciences : CMLS - 1 Apr 2004

Santini S, Derreumaux P

Abstract excerpt

We need to understand the underlying factors that promote or reverse the amyloid-type structure of the prion protein (PrP). In an earlier study, we showed that mutations within the first beta strand can extend the short beta sheet in the normal protein into a larger sheet at neutral pH. To determ...

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Identifiers

PMID: 15095015
DOI: 10.1007/s00018-003-3455-3
PMCID: PMC11138657

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-15095015-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

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