Article
Association study between the -62A/T NFKBIL1 polymorphism and obsessive-compulsive disorder.
Revista brasileira de psiquiatria (Sao Paulo, Brazil : 1999) - 1 Jun 2009
Cordeiro Quirino, Cappi Carolina, Sampaio Aline Santos, Palácios Selma Aliotti, Pereira Carlos Alberto de Bragança, Shavitt Roseli Gedanke, Miguel Eurípedes Constantino, Guilherme Luiza, Hounie Ana Gabriela
Abstract excerpt
OBJECTIVE: Evidence from family and molecular genetic studies support the hypothesis of involvement of immunologic mechanisms in the pathophysiology of obsessive-compulsive disorder. The nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 1 (NFKBIL1) has been suggested as a modulator of the immunological system. Given the importance of NFKBIL1 in the immunological response, the...
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