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Article

TNF-alpha polymorphisms are associated with obsessive-compulsive disorder.

Neuroscience letters - 12 Sept 2008

Hounie Ana Gabriela, Cappi Carolina, Cordeiro Quirino, Sampaio Aline Santos, Moraes Ivanil, Rosário Maria Conceição do, Palácios Selma A, Goldberg Anna Carla, Vallada Homero Pinto, Machado-Lima Ariane, Nakano Eduardo, Kalil Jorge, Pauls David, Pereira Carlos Alberto B, Guilherme Luiza, Miguel Eurípedes Constantino

Abstract excerpt

INTRODUCTION: Several lines of evidence support an immunologic involvement in obsessive-compulsive disorder (OCD): the increased prevalence of OCD in patients with rheumatic fever (RF), and the aggregation of obsessive-compulsive spectrum disorders among relatives of RF probands. Tumor necrosis factor alpha is a proinflammatory cytokine involved in RF and other autoimmune diseases. Polymorphisms in the promoter...

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Identifiers

PMID: 18639610
DOI: 10.1016/j.neulet.2008.07.022

Genes

TNF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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