Article
Human-leukocyte antigen class II genes in early-onset obsessive-compulsive disorder.
The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry - 1 Jun 2019
Rodriguez Natalia, Morer Astrid, González-Navarro E Azucena, Gassó Patricia, Boloc Daniel, Serra-Pagès Carles, Lafuente Amalia, Lazaro Luisa, Mas Sergi
Abstract excerpt
Objective: The exact aetiology of obsessive-compulsive disorder (OCD) is unknown, although there is evidence to suggest a gene-environment interaction model. Several lines of evidence support a possible role of the immune system in this model. Methods: The present study explores the allele variability in HLA genes of class II (HLA-DRB1, HLA-DQB1) in a sample of 144 early-onset OCD compared with reference samples...
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