Article
Biochemical, serological, and genetic aspects related to gene HLA-DQB1 and its association with type 1 diabetes mellitus (T1DM).
Molecular genetics & genomic medicine - 1 May 2020
Singh Gur Charn, Ahmed Mehboob, Zaid Muhammad, Hasnain Shahida
Abstract excerpt
BACKGROUND: Type 1 Diabetes Mellitus (T1DM) is the autoimmune disorder of destruction of β cells of pancreas, creating insulin deficiency condition, which leads to hyperglycemia, polyuria, polydipsia, ketoacidosis, and other metabolic disorder especially in children. Different genetic aspects and environmental factors are involved in pathophysiology of the disease. About 20 genes are associated with this disease...
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