Article
[Distribution and frequency of HLA alleles and haplotypes in Brazilians with type 1 diabetes mellitus].
Arquivos brasileiros de endocrinologia e metabologia - 1 Jun 2006
Alves Crésio, Meyer Isadora, Vieira Nara, Toralles Maria Betânia P, LeMaire Denise
Abstract excerpt
The genetic predisposition to type 1 diabetes (DM1) is associated with genes of the human leukocyte antigen (HLA) system, specially the HLA-DR and -DQ. In Caucasians, the HLA-DR3 and -DR4 antigens are associated with susceptibility and the -DR2, with protection. In Brazil, a country with a large miscegenation of European Caucasians, Native Amerindians and African Blacks, the genetic basis of DM1 has not been...
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