Mitochondrial quality control and communications with the nucleus are important in maintaining mitochondrial function and cell health

Abstract excerpt

BACKGROUND: The maintenance of cell metabolism and homeostasis is a fundamental characteristic of living organisms. In eukaryotes, mitochondria are the cornerstone of these life supporting processes, playing leading roles in a host of core cellular functions, including energy transduction, metabolic and calcium signalling, and supporting roles in a number of biosynthetic pathways. The possession of a discrete...

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