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Mitochondria‐Nuclear Crosstalk: Orchestrating mtDNA Maintenance

26 May 2025

Abstract excerpt

The mitochondria (mt) and nucleus engage in a dynamic bidirectional communication to maintain cellular homeostasis, regulating energy production, stress response, and cell fate. Anterograde signaling directs mt function, while retrograde signaling conveys metabolic and stress-related changes from mt to the nucleus. Central to this crosstalk is mitochondrial DNA (mtDNA), which encodes key oxidative phosphorylation...

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PMID: 40418056
DOI: 10.1002/em.70013

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