Article
Functional characterization of a putative serine carboxypeptidase in vascular smooth muscle cells.
Circulation research - 31 Jul 2009
Lee Ting-Hein, Chen Jiyuan, Miano Joseph M
Abstract excerpt
RATIONALE: We previously identified a novel serine carboxypeptidase, SCPEP1, that undergoes cleavage across all tissues where it is expressed. SCPEP1 bears the signature catalytic triad found in all serine carboxypeptidases, but its biological function is completely unknown. OBJECTIVE: To begin elucidating the functions of SCPEP1 in vitro and in the vessel wall after injury. METHODS AND RESULTS: Cultured smooth...
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