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Article

High-Throughput Screen for Novel Antimicrobials using a Whole Animal Infection Model

29 Jun 2009

Abstract excerpt

The nematode Caenorhabditis elegans is a unique whole animal model system for identifying small molecules with in vivo anti-infective properties. C. elegans can be infected with a broad range of human pathogens, including Enterococcus faecalis, an important human nosocomial pathogen. Here, we describe an automated, high-throughput screen of 37,200 compounds and natural product extracts for those that enhance...

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PMID: 19572548
DOI: 10.1021/cb900084v

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