Article
Whole-organism phenotypic screening for anti-infectives promoting host health.
Nature chemical biology - 1 Apr 2018
Clatworthy Anne E, Romano Keith P, Hung Deborah T
Abstract excerpt
To date, antibiotics have been identified on the basis of their ability to kill bacteria or inhibit their growth rather than directly for their capacity to improve clinical outcomes of infected patients. Although historically successful, this approach has led to the development of an antibiotic armamentarium that suffers from a number of shortcomings, including the inevitable emergence of resistance and, in...
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