Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Identification of antifungal compounds active against Candida albicans using an improved high-throughput Caenorhabditis elegans assay.

PloS one - 14 Sept 2009

Okoli Ikechukwu, Coleman Jeffrey J, Tampakakis Emmanouil, Tempakakis Emmanouil, An W Frank, Holson Edward, Wagner Florence, Conery Annie L, Larkins-Ford Jonah, Wu Gang, Stern Andy, Ausubel Frederick M, Mylonakis Eleftherios

Abstract excerpt

Candida albicans, the most common human pathogenic fungus, can establish a persistent lethal infection in the intestine of the microscopic nematode Caenorhabditis elegans. The C. elegans-C. albicans infection model was previously adapted to screen for antifungal compounds. Modifications to this screen have been made to facilitate a high-throughput assay including co-inoculation of nematodes with C. albicans and...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antifungal Agents
Share to Candida albicans

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Chemistry, Pharmaceutical

Share to Combinatorial Chemistry Techniques

Share to Drug Design

Share to Drug Discovery

Share to Drug Evaluation, Preclinical

Share to Immunosuppressive Agents

Source

Open in PubMed Open full text

Identifiers

PMID: 19750012
DOI: 10.1371/journal.pone.0007025
PMCID: PMC2737148

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Identification of antifungal compounds active against Candida albicans using an improved high-throughput Caenorhabditis elegans assay.PMID 19750012Read ↗

Antifungal Chemical Compounds Identified Using a C. elegans Pathogenicity AssaySemantic proximity Read ↗

Two Infection Assays to Study Non-Lethal Virulence Phenotypes in C. Albicans using C. Elegans.Semantic proximity Read ↗

Targeting fungal membrane homeostasis with imidazopyrazoindoles impairs azole resistance and biofilm formationSemantic proximity Read ↗

Caenorhabditis elegans-Based Aspergillus fumigatus Infection Model for Evaluating Pathogenicity and Drug EfficacySemantic proximity Read ↗

Caenorhabditis elegans as a Model Host to Monitor the Candida Infection ProcessesSemantic proximity Read ↗

Screening for microbial metabolites affecting phenotype of Caenorhabditis elegans.Semantic proximity Read ↗

A novel virulence phenotype rapidly assesses <i>Candida</i> fungal pathogenesis in healthy and immunocompromised <i>Caenorhabditis elegans</i> hostsSemantic proximity Read ↗

A Novel Virulence Phenotype Rapidly Assesses Candida Fungal Pathogenesis in Healthy and Immunocompromised Caenorhabditis elegans HostsSemantic proximity Read ↗

Prokaryote-eukaryote interactions identified by using Caenorhabditis elegans.Semantic proximity Read ↗

Thymol has antifungal activity against Candida albicans during infection and maintains the innate immune response required for function of the p38 MAPK signaling pathway in Caenorhabditis elegans.Semantic proximity Read ↗

Lactobacillus rhamnosus Lcr35 as an effective treatment for preventing Candida albicans infection in the invertebrate model Caenorhabditis elegans: First mechanistic insightsSemantic proximity Read ↗

Fungal Pathogens Research: Novel and Improved Molecular Approaches for the Discovery of Antifungal Drug TargetsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.