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Article

Identification of novel antimicrobials using a live-animal infection model.

Proceedings of the National Academy of Sciences of the United States of America - 5 Jul 2006

Moy Terence I, Ball Anthony R, Anklesaria Zafia, Casadei Gabriele, Lewis Kim, Ausubel Frederick M

Abstract excerpt

The alarming increase of antibiotic-resistant bacterial pathogens points to the need for novel therapeutic approaches to combat infection. To discover novel antimicrobials, we devised a screen to identify compounds that promoted the survival of the model laboratory nematode Caenorhabditis elegans infected with the human opportunistic pathogen Enterococcus faecalis. E. faecalis colonizes the nematode intestinal...

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Identifiers

PMID: 16801562
DOI: 10.1073/pnas.0604055103
PMCID: PMC1482800

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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