Article
Ribonucleotide reductase regulation in response to genotoxic stress in Arabidopsis.
Plant physiology - 1 Sept 2009
Roa Hélène, Lang Julien, Culligan Kevin M, Keller Murielle, Holec Sarah, Cognat Valérie, Montané Marie-Hélène, Houlné Guy, Chabouté Marie-Edith
Abstract excerpt
Ribonucleotide reductase (RNR) is an essential enzyme that provides dNTPs for DNA replication and repair. Arabidopsis (Arabidopsis thaliana) encodes three AtRNR2-like catalytic subunit genes (AtTSO2, AtRNR2A, and AtRNR2B). However, it is currently unclear what role, if any, each gene contributes to the DNA damage response, and in particular how each gene is transcriptionally regulated in response to replication...
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