Article
Caenorhabditis elegans FOS-1 and JUN-1 regulate plc-1 expression in the spermatheca to control ovulation.
Molecular biology of the cell - 1 Sept 2009
Hiatt Susan M, Duren Holli M, Shyu Y John, Ellis Ronald E, Hisamoto Naoki, Matsumoto Kunihiro, Kariya Ken-Ichi, Kerppola Tom K, Hu Chang-Deng
Abstract excerpt
Fos and Jun are components of activator protein-1 (AP-1) and play crucial roles in the regulation of many cellular, developmental, and physiological processes. Caenorhabditis elegans fos-1 has been shown to act in uterine and vulval development. Here, we provide evidence that C. elegans fos-1 and jun-1 control ovulation, a tightly regulated rhythmic program in animals. Knockdown of fos-1 or jun-1 blocks dilation...
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