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Article

Caenorhabditis elegans PIEZO channel coordinates multiple reproductive tissues to govern ovulation.

eLife - 3 Jun 2020

Bai Xiaofei, Bouffard Jeff, Lord Avery, Brugman Katherine, Sternberg Paul W, Cram Erin J, Golden Andy

Abstract excerpt

PIEZO1 and PIEZO2 are newly identified mechanosensitive ion channels that exhibit a preference for calcium in response to mechanical stimuli. In this study, we discovered the vital roles of pezo-1, the sole PIEZO ortholog in Caenorhabditiselegans, in regulating reproduction. A number of deletion alleles, as well as a putative gain-of-function mutant, of PEZO-1 caused a severe reduction in brood size. In vivo...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 32490809
DOI: 10.7554/eLife.53603
PMCID: PMC7340503

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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