Article
Adducts in sperm protamine and DNA vs. mutation frequency.
Progress in clinical and biological research - 1 Jan 1991
Sega G A
Abstract excerpt
In mammals, variability in the genetic sensitivity of different germ-cell stages to mutagens could be the result of how much chemical reaches the different stages, what molecular targets may be affected in the different stages and whether or not repair of lesions occurs. In the mouse, several chemical mutagens have been found that cause their greatest genetic damage in late-spermatid and early-spermatozoa stages...
Topics
- Acrylamide
- Acrylamides
- Alkylation
- Animals
- Binding Sites
- Cysteine
- DNA
- DNA Damage
- Male
- Mice
- Models, Genetic
- Mutagens
- Mutation