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Article

Lead Interaction with Human Protamine (HP2) as a Mechanism of Male Reproductive Toxicity

27 Jun 2000

Abstract excerpt

During spermatogenesis, histones are replaced by protamines, which condense and protect sperm DNA. In humans, zinc contributes to sperm chromatin stability and binds to protamine P2 (HP2). Chemical interactions with nuclear protamines, which prevent normal sperm chromatin condensation, may induce changes in the sperm genome and thus affect fertility and offspring development. Since lead has a high affinity for...

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Identifiers

PMID: 10898591
DOI: 10.1021/tx000017v

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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Lead Interaction with Human Protamine (HP2) as a Mechanism of Male Reproductive ToxicityPMID 10898591Read ↗

P2 protamines from human sperm are zinc -finger proteins with one Cys2His2 motifSemantic proximity Read ↗

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A model for the importance of zinc in the dynamics of human sperm chromatin stabilization after ejaculation in relation to sperm DNA vulnerabilitySemantic proximity Read ↗

Protamine alterations in human spermatozoa.Semantic proximity Read ↗

Human male infertility may be due to a decrease of the protamine P2 content in sperm chromatinSemantic proximity Read ↗

Disturbances of nuclear condensation in human spermatozoa: search for mutations in the genes for protamine 1, protamine 2 and transition protein 1.Semantic proximity Read ↗

[Human male sterility can be caused by mutations in the protamine P2 gene].Semantic proximity Read ↗

Protamine 1: Protamine 2 stoichiometry in the sperm of eutherian mammals*Semantic proximity Read ↗

Protamine 2 precursors, protamine 1/protamine 2 ratio, DNA integrity and other sperm parameters in infertile patientsSemantic proximity Read ↗

Relevance of zinc in human sperm flagella and its relation to motilitySemantic proximity Read ↗

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