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Article

The CGGGG insertion/deletion polymorphism of the IRF5 promoter is a strong risk factor for primary Sjögren's syndrome.

Arthritis and rheumatism - 1 Jul 2009

Miceli-Richard Corinne, Gestermann Nicolas, Ittah Marc, Comets Emmanuelle, Loiseau Pascale, Puechal Xavier, Hachulla Eric, Gottenberg Jacques-Eric, Lebon Pierre, Becquemont Laurent, Mariette Xavier

Abstract excerpt

OBJECTIVE: Interferon regulatory factor 5 is a transcription factor involved in type I interferon (IFN) secretion. This study was undertaken to investigate whether a 5-bp (CGGGG insertion/deletion) promoter polymorphism is involved in genetic predisposition to primary Sjögren's syndrome (SS) and to assess the functional consequences of this polymorphism. METHODS: The exploratory cohort consisted of 185 patients...

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Source

Identifiers

PMID: 19565491
DOI: 10.1002/art.24662

Genes

IFITM1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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