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Article

The interaction of mitochondrial iron with manganese superoxide dismutase.

The Journal of biological chemistry - 21 Aug 2009

Naranuntarat Amornrat, Jensen Laran T, Pazicni Samuel, Penner-Hahn James E, Culotta Valeria C

Abstract excerpt

Superoxide dismutase 2 (SOD2) is one of the rare mitochondrial enzymes evolved to use manganese as a cofactor over the more abundant element iron. Although mitochondrial iron does not normally bind SOD2, iron will misincorporate into Saccharomyces cerevisiae Sod2p when cells are starved for manganese or when mitochondrial iron homeostasis is disrupted by mutations in yeast grx5, ssq1, and mtm1. We report here...

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Identifiers

PMID: 19561359
DOI: 10.1074/jbc.M109.026773
PMCID: PMC2755670

Genes

SOD2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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