Article
Novel V600E BRAF mutations in imatinib-naive and imatinib-resistant gastrointestinal stromal tumors.
Genes, chromosomes & cancer - 1 Oct 2008
Agaram Narasimhan P, Wong Grace C, Guo Tianhua, Maki Robert G, Singer Samuel, Dematteo Ronald P, Besmer Peter, Antonescu Cristina R
Abstract excerpt
BRAF and NRAS are commonly mutated in cancer and represent the most frequent genetic events in malignant melanoma. More recently, a subset of melanomas was shown to overexpress KIT and harbor KIT mutations. Although most gastrointestinal stromal tumors (GISTs) exhibit activating mutations in either KIT or PDGFRA, about 10% of the cases lack mutations in these genes. It is our hypothesis following the melanoma...
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