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Article

Adiponectin deficiency: a model of pulmonary hypertension associated with pulmonary vascular disease.

American journal of physiology. Lung cellular and molecular physiology - 1 Sept 2009

Summer Ross, Fiack Christopher A, Ikeda Yasumasa, Sato Kaori, Dwyer Daniel, Ouchi Noriyuki, Fine Alan, Farber Harrison W, Walsh Kenneth

Abstract excerpt

Adiponectin (APN) is an adipocyte-derived factor that exists at high concentrations in serum and has anti-inflammatory and systemic vascular-protective properties. In this study, we investigated the role of APN in pulmonary vascular homeostasis. We found that APN localizes to the luminal side of blood vessels in lung and acts in vitro to block TNF-alpha-induced E-selectin upregulation in pulmonary artery...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 19561137
DOI: 10.1152/ajplung.90599.2008
PMCID: PMC2739777

Genes

TNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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