Article
Alveolar macrophage activation and an emphysema-like phenotype in adiponectin-deficient mice.
American journal of physiology. Lung cellular and molecular physiology - 1 Jun 2008
Summer R, Little F F, Ouchi N, Takemura Y, Aprahamian T, Dwyer D, Fitzsimmons K, Suki B, Parameswaran H, Fine A, Walsh K
Abstract excerpt
Adiponectin is an adipocyte-derived collectin that acts on a wide range of tissues including liver, brain, heart, and vascular endothelium. To date, little is known about the actions of adiponectin in the lung. Herein, we demonstrate that adiponectin is present in lung lining fluid and that adiponectin deficiency leads to increases in proinflammatory mediators and an emphysema-like phenotype in the mouse lung....
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