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PI3 Kinases in Cancer: From Oncogene Artifact to Leading Cancer Target

12 Dec 2006

Abstract excerpt

At the time of its discovery in the 1980s, the lipid kinase activity found associated with certain viral oncoproteins, which we now know to originate from the class IA phosphatidylinositide 3-kinases (PI3Ks), was thought by many to be a purification artifact. Subsequent work identified these enzymes as key regulators of cell signaling pathways that control various cellular processes including proliferation,...

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PMID: 17164467
DOI: 10.1126/stke.3652006pe52

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