Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Quantification of normal cell fraction and copy number neutral LOH in clinical lung cancer samples using SNP array data.

PloS one - 26 Jun 2009

Göransson Hanna, Edlund Karolina, Rydåker Maria, Rasmussen Markus, Winquist Johan, Ekman Simon, Bergqvist Michael, Thomas Andrew, Lambe Mats, Rosenquist Richard, Holmberg Lars, Micke Patrick, Botling Johan, Isaksson Anders

Abstract excerpt

BACKGROUND: Technologies based on DNA microarrays have the potential to provide detailed information on genomic aberrations in tumor cells. In practice a major obstacle for quantitative detection of aberrations is the heterogeneity of clinical tumor tissue. Since tumor tissue invariably contains genetically normal stromal cells, this may lead to a failure to detect aberrations in the tumor cells. PRINCIPAL...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Carcinoma, Non-Small-Cell Lung
Share to Gene Expression Regulation, Neoplastic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to In Situ Hybridization, Fluorescence

Share to Lasers

Share to Loss of Heterozygosity

Share to Lung Neoplasms

Share to Microdissection

Share to Oligonucleotide Array Sequence Analysis

Source

Open in PubMed Open full text

Identifiers

PMID: 19557126
DOI: 10.1371/journal.pone.0006057
PMCID: PMC2699026

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Quantification of normal cell fraction and copy number neutral LOH in clinical lung cancer samples using SNP array data.PMID 19557126Read ↗

Landscape of somatic allelic imbalances and copy number alterations in human lung carcinomaSemantic proximity Read ↗

High-resolution single-nucleotide polymorphism array and clustering analysis of loss of heterozygosity in human lung cancer cell lines.Semantic proximity Read ↗

Genome-wide allelotyping of lung cancer identifies new regions of allelic loss, differences between small cell lung cancer and non-small cell lung cancer, and loci clustering.Semantic proximity Read ↗

A Challenging Correlation between Tumor Cellularity and Somatic Variant Allele Fraction in Lung and Colorectal Cancers-Specimens of Low Tumor Percentage Should Be Analyzed with Caution.Semantic proximity Read ↗

Genomewide loss of heterozygosity and its clinical associations in non small cell lung cancerSemantic proximity Read ↗

MixHMM: inferring copy number variation and allelic imbalance using SNP arrays and tumor samples mixed with stromal cells.Semantic proximity Read ↗

qpure: A tool to estimate tumor cellularity from genome-wide single-nucleotide polymorphism profiles.Semantic proximity Read ↗

Major copy proportion analysis of tumor samples using SNP arrays.Semantic proximity Read ↗

Comparison of methods to detect copy number alterations in cancer using simulated and real genotyping data.Semantic proximity Read ↗

Haplotype-based profiling of subtle allelic imbalance with SNP arrays.Semantic proximity Read ↗

Loss of heterozygosity in epithelial cells obtained by bronchial brushing: clinical utility in lung cancer.Semantic proximity Read ↗

Genomic landscape of allelic imbalance in premalignant atypical adenomatous hyperplasias of the lungSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.