Article
Nitric oxide-mediated bcl-2 stabilization potentiates malignant transformation of human lung epithelial cells.
American journal of respiratory cell and molecular biology - 1 May 2010
Azad Neelam, Iyer Anand Krishnan V, Wang Liying, Lu Yongju, Medan Djordje, Castranova Vincent, Rojanasakul Yon
Abstract excerpt
Hexavalent chromium (Cr(VI)) compounds are known human carcinogens associated with the incidence of lung cancer. Although a direct correlation between Cr(VI) exposure and lung cancer has been established, several studies aimed at generating animal models for Cr(VI) have yielded inconsistent data that do not affirmatively support findings from epidemiologic studies. Because the lack of a good animal model has...
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