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Article

Chromium(VI) Induces p53-Dependent Apoptosis in Diploid Human Lung and Mouse Dermal Fibroblasts

1 Jan 2000

Abstract excerpt

Some forms of hexavalent chromium [Cr(VI)] are known to cause damage to respiratory-tract tissue and DNA and are thought to be human lung carcinogens. In general, Cr(VI) is mutagenic and carcinogenic at doses that also evoke some cell death, and we previously showed that the predominant mode of death is apoptosis. Because p53 has been shown to initiate apoptosis after genotoxic insults, the objective of these...

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Identifiers

PMID: 10900468
DOI: 10.1002/1098-2744(200006)28:2<111::aid-mc7>3.0.co;2-y

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Chromium(VI) Induces p53-Dependent Apoptosis in Diploid Human Lung and Mouse Dermal FibroblastsPMID 10900468Read ↗

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